Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5

Liu Xiumin; Zhong Lili; Jiang Weidong; Wen Dacheng

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5

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Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5

机译：CircRNA_000684的抑制通过MiR-145介导的KLF5抑制胰腺导管腺癌细胞的恶性表型

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Background: Circular RNAs (circRNAs) are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC). In the current study, we investigated how circRNA_000684 affected the progression of PDAC, and how it regulated kruppel-like factor 5 (KLF5) and microRNA (miR)-145.

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2021年第2期|共12页
作者
Liu Xiumin; Zhong Lili; Jiang Weidong; Wen Dacheng;
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作者单位

Second Hosp Jilin Univ Dept Clin Lab Changchun 130041 Peoples R China;

Second Hosp Jilin Univ Jilin Prov Key Lab Mol &

Chem Genet Changchun 130041 Peoples R China;

Second Hosp Jilin Univ Dept Hepatobiliary &

Pancreat Surg Changchun 130041 PR Peoples R China;

Second Hosp Jilin Univ Dept Gastrointestinal Nutr &

Hernia Surg 218 Ziqiang Rd Changchun 130041;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Pancreatic ductal adenocarcinoma; CircRNA_000684; MicroRNA-145; Kruppel-like factor 5; Migration; Invasion;

机译：胰腺导管腺癌;circrna_000684;microRNA-145;Kruppel样因子5;迁移;入侵;

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1. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma [J] . Junya Peng, Guan-Shen Cui, Ying Yang, 细胞研究（英文版） . 2019,第009期
2. PSC-induced Galectin-1 Promotes the Malignant Behavior of Pancreatic Ductal Adenocarcinoma [J] . Dong Tang, Qi Wu, Hong Peng Zhang, 肿瘤营养学杂志(英文) . 2019,第003期
3. PSC-induced Galectin-1 Promotes the Malignant Behavior of Pancreatic Ductal Adenocarcinoma [J] . Dong Tang, Xiao Ming Sun, Meng Yue Xu, 肿瘤营养学杂志（英文） . 2019,第003期
4. Repression of HNF4 alpha nuclear receptor expression promotes malignant properties of human pancreatic ductal adenocarcinoma cells [J] . Chesnokov M. S., Lazarevich N. L. The FEBS journal . 2015,第Suppla1期

机译：HNF4α核受体表达的抑制促进人类胰腺导管腺癌细胞的恶性特性。
5. Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma [J] . Yalu Zhang, Qiaofei Liu, Sen Yang, Molecular Therapy - Oncolytics . 2021,第a期

机译：LRRN1的敲低通过调节HIF-1α/ Notch途径在胰腺导管腺癌中的调节抑制恶性表型
6. Silencing of pancreatic adenocarcinoma upregulated factor by RNA interference inhibits the malignant phenotypes of human colorectal cancer cells [J] . LiuP.-F., WuY.-Y., HuY., Oncology reports . 2013,第1期

机译：RNA干扰沉默胰腺癌上调因子抑制人大肠癌细胞的恶性表型
7. Real-time and non-invasive quantitative phase imaging of pancreatic ductal adenocarcinoma cell mechanical properties [C] . D Gillies, W Gamal, M Canel, Optical Elastography and Tissue Biomechanics VI . 2019

机译：胰腺导管腺癌细胞力学特性的实时和非侵入性定量成像
8. Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells. [D] . Jimbo, Masaya. 2015

机译：靶向mRNA结合蛋白HuR会损害胰腺导管腺癌细胞的恶性特征。
9. Up‐regulation of CDHR5 expression promotes malignant phenotype of pancreatic ductal adenocarcinoma [O] . Junyi Gao, Mengyi Wang, Tong Li, 2020

机译：CDHR5表达的上调促进胰腺腺癌的恶性表型
10. ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice [O] . Yoshito Kimura, Akihisa Fukuda, Satoshi Ogawa, 2018

机译：Arid1a保持胰腺导管细胞的分化并抑制小鼠胰腺导管腺癌的发展
11. Inhibition of Pancreatic Cancer Cell Proliferation by LRH-1 Inhibitors. [R] . Fletterick, R. J. 2014

机译：LRH-1抑制剂对胰腺癌细胞增殖的抑制作用。

Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5

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