A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry

摘要

In this work, a novel labelling reagent with multi-charges was designed and developed for glycans capillary electrophoresis-mass spectrometry (CE-MS) analysis. Glycans labelled with this reagent have multiple charges. The results showed that the separation efficiencies of glycans were improved and the sensitivities of large glycans were enhanced more than 10 fold.