Self-assembled Mn-doped ZnSe quantum dot-methyl viologen nanohybrids as an OFF-ON fluorescent probe for time-resolved fluorescence detection of tiopronin

摘要

The improvement of analytical accuracy and SIN (signal to noise ratio) based on conventional homogeneous fluorometry was always limited because of high background noise from complicated sample ingredients, buffer solution and lysates. Herein, a self-assembled Mn-doped ZnSe quantum dot-methyl viologen nanohybrid as an OFF-ON fluorescent probe is presented for the time-resolved fluorescence detection of tiopronin, showing high SIN and selectivity with a low detection limit of 0.1 umol L~(-1) and a linear response ranging from 4 to 160 nM. We anticipate that this probe will have promising applications for sensitive biosensing and drug analysis.