Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity

摘要

Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-kappa B signaling in T cells of tumor-bearing hosts with a potential to overcome cancer cell resistance to therapy.