Synthesis, Characterisation, and Antibacterial Activity of Some Novel Vanillin Related Hydrazone Derivatives Bearing 1,2,3-Triazole Ring

摘要

Vanillin, hydrazone and 1,2,3-triazole containing functional groups derivatives demonstrate antibacterial activity. In the present work, we present synthesis of eight new vanillin related hydrazone derivatives bearing 1,2,3-triazole ring skeleton 9a-9e, 10a-10e obtained with high yields by the coupling of aldehydes 6 and 7 with substituted benzohydrazides 8a-8e in ethanol. IR, NMR and MS data and elemental analysis confirm the structures of products. All title compounds were evaluated in vitro for their antibacterial activity against a panel of Gram positive and Gram negative bacteria and compounds 9d and 10d exhibited high activity.