Determination of scalp hair selenium concentrations in Algerian psoriatic individuals using k(0)-standardization based on neutron activation analysis method

摘要

Psoriasis is a dermatological disease that affects 23% of the Algerian population. Selenium has a positive impact on psoriasis. Selenium plays an important role in protecting free radical damage as a component of the glutathione peroxidase enzyme. The objective of this investigation was to assess the status of selenium in the hair of Algerian patients suffering from psoriasis. Fifty-eight scalp hair samples were collected from Algerian patients with psoriasis, classified by gender and four age groups: 36 females and 22 males, aged between 9 and 79 years. Thirty healthy subjects aged 9-74 years were also surveyed for control purposes. Selenium content was measured for all scalp hair samples using the k(0)-standardization of neutron activation analysis. The average selenium concentration for controls and patients were 0.39 +/- 0.18 and 0.28 +/- 0.13 mu g/g respectively. Selenium concentration for female and male controls and patients, were 0.35 +/- 0.17, 0.47 +/- 0.19, 0.28 +/- 0.14, and 0.28 +/- 0.11 mu g/g, respectively. There is a significant difference (p < 0.05) between selenium level in patients and in controls. Selenium concentrations in psoriatics' scalp hair can be affected by both gender and age. Measured seleniumcontents have been approved by the quality assurance and quality control procedure (QA/QC).