Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

Nag Sukriti; Yu Lei; Capuano Ana W.; Wilson Robert S.; Leurgans Sue E.; Bennett David A.; Schneider Julie A.

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Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

机译：衰老和阿尔茨海默病患者的海马硬化和TDP-43病理

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ObjectiveTo investigate the association of hippocampal sclerosis (HS) with TAR-DNA binding protein of 43kDa (TDP-43) and other common age-related pathologies, dementia, probable Alzheimer disease (AD), mild cognitive impairment (MCI), and cognitive domains in community-dwelling older subjects.

机译：目的探讨海马硬化（HS）与43kDa TAR-DNA结合蛋白（TDP-43）以及其他常见的年龄相关性病理，痴呆，可能的阿尔茨海默病（AD），轻度认知障碍（MCI）和认知域的关系在社区居住的较老科目中。

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《Annals of neurology》 |2015年第6期|共11页
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Nag Sukriti; Yu Lei; Capuano Ana W.; Wilson Robert S.; Leurgans Sue E.; Bennett David A.; Schneider Julie A.;
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正文语种 eng
中图分类神经病学;
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1. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons [J] . Cykowski Matthew D., Takei Hidehiro, Van Eldik Linda J., Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc . 2016,第5期

机译：海马硬化而不是正常衰老或老年痴呆症与老年人基底前脑的TDP-43病理学相关
2. TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's Syndrome: association with age, hippocampal sclerosis and clinical phenotype. [J] . Davidson YS, Raby S, Foulds PG, Acta Neuropathologica . 2011,第6期

机译：TDP-43早发性家族和偶发性阿尔茨海默氏病，晚发性阿尔茨海默氏病和唐氏综合症的病理变化：与年龄，海马硬化和临床表型有关。
3. TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype [J] . Yvonne S. Davidson, Samantha Raby, Penelope G. Foulds, Acta Neuropathologica . 2011,第6期

机译：TDP-43早期家族性和偶发性阿尔茨海默氏病，晚期晚期阿尔茨海默氏病和唐氏综合症的病理变化：与年龄，海马硬化和临床表型的关系
4. In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease [C] . Phelix Clyde F., LeBaron Richard G., Roberson Dawnlee J., 11th IEEE International Conference on Data Mining Workshops . 2011

机译：体内和计算机证据：随着年龄的增长，海马胆固醇代谢减少，而阿尔茨海默氏病则增加—模拟脑衰老和疾病
5. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease [D] . Lehrer, Helaina Jessica Skop 2015

机译：使用动物和基于细胞的疾病模型研究RNA结合蛋白TDP-43在肌萎缩性侧索硬化中的作用
6. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons [O] . Matthew D. Cykowski, Hidehiro Takei, Linda J. Van Eldik, -1

机译：海马硬化而不是正常的衰老或阿尔茨海默氏病与老年人基底前脑的TDP-43病理相关
7. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons [O] . Matthew D. Cykowski, Hidehiro Takei, Linda J. Van Eldik, 2016

机译：海马硬化，但不是正常的老化或阿尔茨海默病与年龄的基础前脑中的TDP-43病理有关

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

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