Glucose-containing imidazolium salt-catalyzed cross-aldol reaction of isatins and unactivated ketones

摘要

Ketone-ketone cross-aldol reaction of isatins and unactivated ketones was catalyzed by glucose-containing imidazolium salt beta-1-imidazole-2,3,4,6-tetra-o-hydroxy-d-glucopyranosyl bromide in neutral condition to generate 3-alkyl-3-hydroxyindolin-2-ones in excellent yield.