Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

Irwin David; Grossman Murray; Weintraub Daniel; Hurtig Howard I.; Duda John E.; Xie Sharon X.; Lee Edward B.; Van Deerlin Vivianna M.; Lopez Oscar L.; Kofler Julia K.; Nelson Peter T.; Jicha Gregory A.; Woltjer Randy; Quinn Joseph F.; Kaye Jeffery; Leverenz James B.; Tsuang Debby; Longfellow Katelan; Yearout Dora; Kukull Walter; Keene C. Dirk; Montine Thomas J.; Zabetian Cyrus P.; Trojanowski John Q.

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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

机译：孕核视察中生存和痴呆发病的神经病理和遗传相关性：回顾性分析

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Background Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synudeinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of dinical heterogeneity in synudeinopathies.

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《Lancet Neurology》 |2017年第1期|共11页
作者
Irwin David; Grossman Murray; Weintraub Daniel; Hurtig Howard I.; Duda John E.; Xie Sharon X.; Lee Edward B.; Van Deerlin Vivianna M.; Lopez Oscar L.; Kofler Julia K.; Nelson Peter T.; Jicha Gregory A.; Woltjer Randy; Quinn Joseph F.; Kaye Jeffery; Leverenz James B.; Tsuang Debby; Longfellow Katelan; Yearout Dora; Kukull Walter; Keene C. Dirk; Montine Thomas J.; Zabetian Cyrus P.; Trojanowski John Q.;
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Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Dept Neurol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

Univ Pittsburgh Dept Neurol Pittsburgh PA 15260 USA;

Univ Pittsburgh Sch Med Dept Pathol Pittsburgh PA USA;

Univ Kentucky Sanders Brown Ctr Aging Lexington KY 40536 USA;

Univ Kentucky Sanders Brown Ctr Aging Lexington KY 40536 USA;

Oregon Hlth &

Sci Univ Dept Pathol Portland OR 97201 USA;

Oregon Hlth &

Sci Univ Dept Neurol Portland OR 97201 USA;

Oregon Hlth &

Sci Univ Dept Neurol Portland OR 97201 USA;

Cleveland Clin Fdn Cleveland Clin Lou Ruvo Ctr Brain Hlth 9500 Euclid Ave Cleveland OH 44195;

Univ Washington Sch Med Dept Psychiat &

Behav Sci Seattle WA USA;

Univ Washington Sch Med Dept Neurol Seattle WA USA;

Univ Washington Sch Med Dept Neurol Seattle WA USA;

Univ Washington Sch Med Dept Epidemiol Seattle WA USA;

Univ Washington Sch Med Dept Pathol Seattle WA USA;

Standford Univ Dept Pathol Stanford CA USA;

Univ Washington Sch Med Dept Neurol Seattle WA USA;

Univ Penn Perelman Sch Med Ctr Neurodegenerat Dis Res Dept Pathol Philadelphia PA 19104 USA;

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正文语种 eng
中图分类神经病学与精神病学;
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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

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