Familial multiple myeloma: first case reported in a Mexican family.

摘要

Multiple myeloma (MM) is a malignant plasma cell tumor that is distributed at multiple sites within the bone marrow compartments . This disseminated malignancy is diagnosed in approximately 14,500 Americans each year and, though treatable, accounts for 2% of all cancer deaths and remains incurable. We report on a family in which three members in two generations are affected with MM (Fig. 1). All of the relatives affected with breast cancer developed ductal carcinoma with hormone receptors positive at the age of 65 and 66 years respectively. There were no additional risk factors for breast cancer. Patients with MM were diagnosed as stage II in one case and stage IE in the others according to The International Staging System for Multiple Myeloma. Karyotypic analysis by G. T.G. banding revealed no abnormalities in both patients. The first case of MM was developed in a 56-year-old woman who was previously diagnosed with breast cancer. She received melphalan/prednisone for 12 months, developing a fatal pneumonia associated to disease progression.