Antifungal Susceptibility of Candida Bloodstream Isolates Collected During a 10-Year Period in Austria

摘要

Objectives: We assessed the current status quo of clinical Candida bloodstream isolates collected from several hospitals all over Austria between 2007 and 2016. We determined antifungal resistance and abundance and explored subsets of each Candida spp. Methods: More than 1300 clinical Candida isolates from blood cultures were tested against fluconazole (FLZ), voriconazole (VOR), posaconazole (POS), itraconazole (ITR), isavuconazole (ISA), anidu-lafungin (ANI), caspofungin (CAS) and micafungin (MCA) according to the EUCAST method of broth microdilution with additional recording of the growth curves. Minimal inhibitory concentrations (MIC) were quantified according to EUCAST guideline E.DEF 7.3.1 and resistance was evaluated using clinical breakpoints provided by EUCAST.