Successful cholecystectomy in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria during eculizumab treatment

摘要

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder that is commonly associated with aplastic anemia (AA) and is characterized by chronic intravascular hemolysis and a highly increased risk of thrombosis [1]. Severe infections and surgical procedures can place patients with PNH at risk for elevated hemolysis [1]. Herein, we report the case of a patient with AA and PNH (AA-PNH) who underwent open surgical resection of the gallbladder during maintenance treatment with eculizumab. Although open surgery poses a high risk for patients with PNH, the patient underwent a safe cholecystectomy with eculizumab pretreatment.