Suppression of Development of Vancomycin-Resistant Staphylococcus epidermidis by Low-Molecular-Weight Cationic Peptides of the Lantibiotic Family

摘要

Low-molecular-weight cationic peptides warnerin and hominin activate the autolytic systems and cause cell death of Staphylococcus epidermidis 33 GISK, as well as its vancomycin-resistant variant. Minimal bactericidal concentrations of warnerin for both strains studied were determined. Efficiency of antibacterial action of the peptide was found to depend directly on its concentration. Comparative investigation of adhesive properties and biofilm-forming ability of two strains was carried out. The cationic peptide warnerin was found to suppress biofilm formation by both vancomycin-sensitive and resistant strains of S. epidermidis 33 GISK and to have a pronounced destructuring effect on formed biofilms.