The neuropeptide Cholecystokinin (CCK) is one of the major regulators of bile excretion and pancreatic enzyme secretion. The rat CCK gene was cloned and sequenced by Deschenes et al (1984, Proc NAS, 81, 726-730) and subsequently CCK gene expression has been demonstrated in rat and mouse duodenal and brain tissue as well as in some human cell lines. Although there is convincing evidence that CCK also has a physiological role as a regulator of satiety in monogastrics, the role of CCK in the control offeed intake in ruminants has not yet been established. In this study, we report the use molecular biology techniques to demonstrate CCK gene expression in the bovine duodenum.
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