Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

Keskin Mutlu; Lahteenmaki Hanna; Rathnayake Nilminie; Raisanen Ismo T.; Tervahartiala Taina; Parnanen Pirjo; Senisik Ahmet Murat; Karacetin Didem; Balkanay Ayben Yentek; Heikkila Pia; Hagstrom Jaana; Rautava Jaana; Haglund Caj; Gursoy Ulvi Kahraman; Silbereisen Angelika; Bostanci Nagihan; Sorsa Timo

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Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

机译：活性基质金属蛋白酶-8和白细胞介素-6检测由头部和颈部癌症放射治疗引起的牙周退化：试验研究

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Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy.

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来源
《Expert review of proteomics》 |2020年第12期|共8页
作者
Keskin Mutlu; Lahteenmaki Hanna; Rathnayake Nilminie; Raisanen Ismo T.; Tervahartiala Taina; Parnanen Pirjo; Senisik Ahmet Murat; Karacetin Didem; Balkanay Ayben Yentek; Heikkila Pia; Hagstrom Jaana; Rautava Jaana; Haglund Caj; Gursoy Ulvi Kahraman; Silbereisen Angelika; Bostanci Nagihan; Sorsa Timo;
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作者单位

Altinbas Univ Oral &

Dent Hlth Dept Istanbul Turkey;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Altinbas Univ Radiotherapy Dept Istanbul Turkey;

Baakehir Cam &

Sakura City Hosp Radiat Oncol Dept Istanbul Turkey;

Baakehir Cam &

Sakura City Hosp Radiat Oncol Dept Istanbul Turkey;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Turku Dept Oral Pathol &

Radiol Turku Finland;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

Univ Helsinki Res Programs Unit Translat Canc Med Helsinki Finland;

Univ Turku Inst Dent Dept Periodontol Turku Finland;

Karolinska Inst Dept Dent Med Div Oral Dis Sect Periodontol &

Dent Prevent Stockholm Sweden;

Karolinska Inst Dept Dent Med Div Oral Dis Sect Periodontol &

Dent Prevent Stockholm Sweden;

Univ Helsinki Helsinki Univ Hosp Dept Oral &

Maxillofacial Dis Helsinki Finland;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
aMMP-8; head and neck cancer; Il-6; periodontitis; point of care technology; radiotherapy;

机译：AMMP-8;头部和颈部癌;IL-6;牙周炎;护理点技术;放射疗法;

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专利

1. Correlation of matrix metalloproteinase－2, －9, tissue inhibitor－1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis [J] . 徐娅苹, 赵学群, SOMMERK., 浙江大学学报：自然科学英文版 . 2003,第004期
2. Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis [J] . 浙江大学学报（英文版）（A辑：应用物理和工程） . 2003,第004期
3. The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy [J] . Ahmed I.Ghanem, Matthew Schymick, Souheyla Bachiri, 世界耳鼻咽喉头颈外科杂志（英文） . 2019,第003期
4. The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy [J] . Ahmed I.Ghanem, Matthew Schymick, Souheyla Bachiri, 世界耳鼻咽喉头颈外科杂志（英文） . 2019,第003期
5. Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer. [J] . Pradhan Palikhe P, Vesterinen T, Tarkkanen J, Oral oncology . 2010,第7期

机译：基质金属蛋白酶-1的组织抑制剂的血浆水平而非基质金属蛋白酶-8的组织抑制剂的血浆水平预示着头颈部鳞状细胞癌的存活。
6. The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E-2 levels in patients with rheumatoid arthritis [J] . Kurgan S., Fentoglu O., Onder C., Journal of periodontal research . 2016,第5期

机译：牙周治疗对类风湿关节炎患者龈沟液基质金属蛋白酶8，白介素6和前列腺素E-2的影响
7. Active matrix metalloproteinase-8 and periodontal bacteria depending on periodontal status in patients with rheumatoid arthritis [J] . Kirchner A., Jaeger J., Krohn-Grimberghe B., Journal of periodontal research . 2017,第4期

机译：活性基质金属蛋白酶-8和牙周细菌，取决于类风湿性关节炎患者的牙周病
8. The Clinical Analysis on Acute Oral Cavity Mucositis Caused by the Radiotherapy for the Head and Neck Cancer [C] . Hongying Lin, Min Ma, Shengcun Zhang International Forum on Bioinformatics and Medical Engineering . 2015

机译：急性口腔粘膜肌炎术治疗头颈癌的临床分析
9. Symptoms, symptom distress, depressive symptoms, and uncertainty in newly diagnosed head and neck cancer patients receiving definitive radiotherapy with or without chemotherapy [D] . Haisfield-Wolfe, Mary Ellen 2009

机译：新诊断头颈癌患者接受明确放疗并伴或不伴化疗的症状，症状困扰，抑郁症状和不确定性
10. Prospective Pilot Study Comparing the Need for Adaptive Radiotherapy in Unresected Bulky Disease and in Postoperative Patients With Head and Neck Cancer [O] . Omar Mahmoud, Isildinha M. Reis, Michael M. Samuels, 2017

机译：前瞻性研究比较未切除的大块疾病和头颈癌术后患者适应性放疗的需求
11. Long-term outcome of radiotherapy-induced taste dysfunction in head and neck cancer patients: A pilot study [O] . Guedea Marc, Parra Andrea, Vinals Helena, 2020

机译：放射治疗诱导的头颈癌患者味道功能障碍的长期结果：试验研究
12. Conozca Sobre la Radioterapia en el Cancer de Cabeza y Cuello: Guia para Adultos y Personas que Ayudan a su Cuidado (Understanding Radiotherapy for Head and Neck Cancer: A Guide for Adults and Their Caregivers). [R] . 2010

机译：Conozca sobre la Radioterapia en el Cancer de Cabeza y Cuello：Guia para adultos y personas que ayudan a su Cuidado（了解头颈癌的放射治疗：成人及其护理人员指南）。

Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

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