Hypogammaglobulinemia treated with infusion therapy associated with cortisol deficiency

摘要

Hypogammaglobulinemia is an inclusive term that encompasses all primary immunodeficiency states with low immunoglobulin or low antibody function. It is characterized by blighted B differentiation with faulty immunoglobulin production. Antibody deficiency characteristically leads to recurrent, often severe, upper and lower respiratory tract infections, usually with encapsulated bacteria.1 The clinical diverseness of the disease implies that multiple immunological defects can result in the ultimate consequence of hypogammaglobulinemia. The clinical course may be complicated with various autoimmune, endocrinological disorders and malignancies.2 We present 5 white female patients with hypogammaglobulinemia without decreased cortisol levels presenting with generalized fatigue and weakness.