Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

Bouhnik Yoram; Carbonnel Franck; Laharie David; Stefanescu Carmen; Hebuterne Xavier; Abitbol Vered; Nachury Maria; Brixi Hedia; Bourreille Arnaud; Picon Laurence; Bourrier Anne; Allez Matthieu; Peyrin-Biroulet Laurent; Moreau Jacques; Savoye Guillaume; Fumery Mathurin; Nancey Stephane; Roblin Xavier; Altwegg Romain; Bouguen Guillaume; Bommelaer Gilles; Danese Silvio; Louis Edouard; Zappa Magaly; Mary Jean-Yves

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Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

机译：Adalimalab在克罗恩病和症状小肠梗塞患者中的疗效：多方面，前瞻性，观察队列（克里奥尔）研究

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Objective The efficacy of anti-tumour necrosis factors (anti-TNFs) in patients with Crohn's disease (CD) and symptomatic small bowel stricture (SSBS) is controversial. The aim of this study was to estimate the efficacy of adalimumab in these patients and to identify the factors predicting success.

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来源
《Gut: Journal of the British Society of Gastroenterology》 |2018年第1期|共8页
作者
Bouhnik Yoram; Carbonnel Franck; Laharie David; Stefanescu Carmen; Hebuterne Xavier; Abitbol Vered; Nachury Maria; Brixi Hedia; Bourreille Arnaud; Picon Laurence; Bourrier Anne; Allez Matthieu; Peyrin-Biroulet Laurent; Moreau Jacques; Savoye Guillaume; Fumery Mathurin; Nancey Stephane; Roblin Xavier; Altwegg Romain; Bouguen Guillaume; Bommelaer Gilles; Danese Silvio; Louis Edouard; Zappa Magaly; Mary Jean-Yves;
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作者单位

Univ Paris Diderot Hop Beaujon PMAD DHU UNITY CRI UMR 1149 Inserm Labex Inflamex Gastroenterol;

Hop Bicetre Gastroenterol Le Kremlin Bicetre France;

Hop Haut Leveque Hepatogastroenterol &

Oncol Digest Pessac France;

Hop Beaujon MICI &

Assistance Nutrit Gastroenterol Clichy France;

Hop Archet 2 Gastroenterol &

Nutr Clin Nice France;

Hop Cochin Gastroenterol Paris France;

Hop Claude Huriez Maladies Appareil Digestif &

Nutr Lille France;

Hop Robert Debre Gastroenterol Reims France;

Hop Hotel Dieu Hepatogastroenterol &

Cancerol Digest Nantes France;

Hop Trousseau Hepatogastrooncoenterol Tours France;

Hop St Antoine Gastroenterol &

Nutr Paris France;

Hop St Louis Hepatogastroenterol Paris France;

Hop Brabois Hepatogastroenterol Nancy France;

Hop Rangueil Gastroenterol &

Nutr Toulouse France;

Hop Charles Nicolle Hepatogastroenterol &

Nutr Rouen France;

Hop Nord Amiens Hepatogastroenterol Amiens France;

Ctr Hosp Lyon Sud Hepatogastroenterol Lyon France;

CHU St Etienne Gastroenterol &

Hepatol St Etienne France;

Hop St Eloi Hepatogastroenterol Montpellier France;

Hop Pontchaillou Maladies Appareil Digestif Rennes France;

CHU Estain Hepatol Gastroenterol Clermont Ferrand France;

Inst Clin Humanitas Dept Gastroenterol Milan Italy;

Univ Liege CHU Sart Tilman Gastroenterol Liege Belgium;

Hop Beaujon Radiol Clichy France;

Denis Diderot Paris 7 Univ Hop St Louis INSERM UMR S 1153 Paris France;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study [J] . Bouhnik Yoram, Carbonnel Franck, Laharie David, Gut: Journal of the British Society of Gastroenterology . 2018,第1期

机译：Adalimalab在克罗恩病和症状小肠梗塞患者中的疗效：多方面，前瞻性，观察队列（克里奥尔）研究
2. Efficacy of Endoscopic Balloon Dilation for Small Bowel Strictures in Patients With Crohn's Disease: A Nationwide, Multi-centre, Open-label, Prospective Cohort Study [J] . Hirai Fumihito, Andoh Akira, Ueno Fumiaki, Journal of Crohn’s & colitis . 2018,第4期

机译：克罗恩病患者内镜球囊扩张对小肠狭窄的疗效：全国范围，多中心，开放式，未来的队列研究
3. Efficacy and safety of short-term adalimumab treatment in patients with active Crohn's disease who lost response or showed intolerance to infliximab: a prospective, open-label, multicentre trial. [J] . Hinojosa J, Gomollon F, Garcia S, Alimentary pharmacology & therapeutics. . 2007,第4期

机译：短期阿达木单抗在活动性克罗恩病患者中失去反应或对英夫利昔单抗不耐受的有效性和安全性：一项前瞻性，开放性，多中心试验。
4. The clinical cohort study on prospective efficacy of CHD Therapeutic Regimen of “the regulation of Pi(Spleen) and protection of Xin(Heart)” method treating CHD patients [C] . Danping Xu, Xia Wang, Wenjie Luo, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：“ Pi（脾）的调节和心（心）的保护”法治疗冠心病的冠心病治疗方案前瞻性临床队列研究
5. Endoscopic balloon dilation vs. strictureplasty in the treatment of naive strictures in Crohn's Disease patients. [D] . Novy, Aaron J. 2011

机译：内窥镜球囊扩张与狭窄成形术在克罗恩病患者中天真的狭窄的治疗。
6. Original article: Efficacy of adalimumab in patients with Crohns disease and symptomatic small bowel stricture: a multicentre prospective observational cohort (CREOLE) study [O] . Yoram Bouhnik, Franck Carbonnel, David Laharie, -1

机译：原始文章：阿达木单抗在克罗恩病和有症状小肠狭窄患者中的疗效：一项多中心前瞻性观察性队列研究（CREOLE）
7. Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study [O] . Bouhnik, Yoram, Carbonnel, Franck, Laharie, David, 2017

机译：阿达木单抗在克罗恩病和有症状小肠狭窄患者中的疗效：一项多中心，前瞻性，观察性队列研究（CREOLE）
8. Potential Utility of Urinary Biomarkers for Risk Prediction in Combat Casualties: A Prospective Observational Cohort Study. [R] . Stewart, I. J., Glass, K. R., Howard, J. T., 2015

机译：尿生物标志物用于战斗伤员风险预测的潜在效用：一项前瞻性观察性队列研究。

Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

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