Normal IgG and IgA levels in IgM-deficient patients: a review of 93 cases. American College of Allergy, Asthma, & Immunology

摘要

The study by Goldstein and colleagues provides great detail on individual cases in which an IgM deficiency was noted in their patients. Although they found that the group average values for IgA and IgG were within the reference ranges at 186 and 937 mg/dL, respectively, for the 36 cases of IgM deficiency extracted from their database of 13,700 patients, a trend toward subnormal values in a subpopulation cannot be completely excluded from the data presented in their article. Therefore, IgG values for each case were graphed herein in relation to the corresponding IgA values; this analysis also included data from 57 other published cases found in Table 2.1 As shown in Figure 1, no definite subpopulations of abnormally low IgG or IgA values were found in IgM-deficient individuals (reference ranges, 694-1,618 and 81-463 mg/dL, respectively).