Successful desensitization with temozolomide.

摘要

Temozolomide is an oral alkylating agent used for the treatment of aggressive brain tumors, such as grade IV astrocytoma, glioblastoma multiforme, and melanoma. Allergic reactions to alkylating agents are uncommon. Hypersensitivity reactions to temozolomide have been described, such as urticaria, hypersensitivity pneumonitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.