Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine

摘要

Curative effect of magnesium sulfate combined with nifedipine on pregnancy-induced hypertension and the effect of serum inflammatory factors were investigated. A total of 188 cases of patients were collected as the research subjects. They all had pregnancy-induced hypertension, and were admitted to The First People's Hospital of Yunnan Province hospital from June 2016 to February 2018. There were, 94 patients treated with magnesium sulfate in the control group, and further 94 patients treated with magnesium sulfate combined with nifedipine in the study group. ELISA was used to detect the expression levels of suppressors of cytokine signaling-3 (SOCS-3), interleukin-10 (IL-10) and interleukin 18 (IL-18), and the relationship between serum inflammatory factors and efficacy was analyzed. The curative effect and eutocia rate in the study group were significantly higher than those in the control group (P<0.05), and the cesarean section rate was lower than that of the control group (P<0.05). In the study group, the adverse reactions were significantly lower than those in the control group (P<0.05). After treatment, the expression levels of serum SOCS-3 and IL-10 in the study group were significantly higher than those in the control group (P<0.05), while the expression level of serum IL-18 was significantly lower than that in the control group (P<0.05). The area under the curve (AUC) of the predictive value of SOCS-3, IL-10 and IL-18 in pregnancy-induced hypertension was 0.717, 0.727 and 0.725, respectively. The best specificity was 76.19, 52.98 and 61.90%, respectively, when the cut-off value was <0.553 ng/l, 48.06 ng/ml and 269.46 ng/ml, and their sensitivity was 70.00, 94.74 and 85.00%, respectively. In conclusion, magnesium sulfate combined with nifedipine significantly improved the disease course of pregnancy-induced hypertension. The levels of SOCS-3, IL-10 and IL-18 in patients are correlated with the curative effect of pregnancy-induced hypertension, suggesting that they have important value in the treatment and monitoring of gestational hypertension.