Correlations of cardiac function with inflammation, oxidative stress and anemia in patients with uremia

摘要

The present study aimed to analyze the associations of cardiac function with inflammatory cytokines, oxidative stress and anemia in patients with uremia. A total of 79 patients with uremia were selected, and among those, 43 cases were complicated with cardiac dysfunction (observation group) and 36 patients were not (control group). The levels of inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10], oxidative stress indicators [malondialdehyde (MDA), oxidized low-density lipoprotein (OX-LDL) and advanced oxidation protein products (AOPP)], blood routine parameters [hemoglobin (Hb), platelets (PLT), mean corpuscular volume (MCV)], and cardiac function [including cardiac output (CO), cardiac stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd)] were measured. There were no statistically significant differences in age, sex, body mass index, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol between the observation and the control group (P>0.05), but the observation group had significantly higher triglyceride levels and blood pressure, as well as longer duration of uremia compared with those in the control group (P<0.05). Furthermore, the levels of CRP, IL-6, IL-10, MDA, OX-LDL, AOPP, Hb, PLT and MCV in the observation group were significantly higher than those in the control group. In addition, regarding cardiac function, the observation group had a decreased CO, SV and LVEF and an increased LVEDd and LVESd compared with those in the control group. Furthermore, CRP (r=-0.636, P<0.01) and MDA (r=-0.705, P<0.01) were negatively correlated with LVEF, while Hb levels were positively correlated with LVEF (r=0.732, P<0.001). In conclusion, serum inflammatory cytokines, oxidative stress and the degree of anemia are associated with cardiac insufficiency in patients with uremia.