IL-17RB(+) granulocytes are associated with airflow obstruction in asthma

摘要

Background: Interleukin (IL)-25 (IL-17E) is a proinflammatory cytokine that plays an important role in the T-helper type 2 cell pathway. The effects of IL-25 are mediated by its specific receptor, IL-17RB. Previous studies have defined an IL-17RB(+) granulocyte population known as type 2 myeloid (T2M) cells that express T-helper type 2 cell cytokines. The correlation of IL-17RB(+) granulocytes, T2M cells, and asthma parameters is unknown.