Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial 'NIMBUS'

Grimm Marc-Oliver; van der Heijden Antoine G.; Colombel Marc; Muilwijk Tim; Martinez-Pineiro Luis; Babjuk Marko M.; Turkeri Levent N.; Palou Joan; Patel Anup; Bjartell Anders S.; Caris Christien; Schipper Raymond G.; Witjes Wim P. J.; Horstmann Joerg; Machtens Stefan; Mumperow Eberhard; Al Ghazal Andreas; Pulte Thomas; Stephan-Odenthal Michael; Gakis Georgios; Kramer Mario; Zaak Dirk; Schmitz-Draeger Bernd; Schreier Holger; Lehmann Jan; Werner Torsten; Klier Joerg; Marin Jan; Rulf Wolfgang; Hellmis Eva; Schneider Andreas; Spiegelhalder; Wirth Manfred; Klotz Theodor; Suttmann Henrik; Siebels Michael; Rodemer Gerd; Rudolph Robert; Zillmann Roger; de Bruin M.; Bos S.; van Moorselaar R.; de Reijke T.; Boormans J.; Wijsman B.; van Melick H. H. E.; van Boven E.; Meijer R. P.; van der Heijden A. G.; Vergunst H.; te Slaa E.; Leliveld-Kors A. M.; Ruffion Alain; Pfister Christian; Roupret Morgan; Irani Jacques; Stoica Gabriel; Van Bruwaene Siska; Ameye Filip; Arentsen Harm; Joniau Steven; Beardo Pastora

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Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial 'NIMBUS'

机译：通过标准数量和BCG滴注剂量治疗高档非肌肉侵入性膀胱癌与BCG滴注的减少数量和标准剂量：欧洲泌尿外科协会的结果随机化期III临床试验“Nimbus”

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摘要

Background: Intravesical instillation of bacillus Calmette-Guerin (BCG) is an accepted strategy to prevent recurrence of non-muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity.

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来源
《European urology》 |2020年第5期|共9页
作者
Grimm Marc-Oliver; van der Heijden Antoine G.; Colombel Marc; Muilwijk Tim; Martinez-Pineiro Luis; Babjuk Marko M.; Turkeri Levent N.; Palou Joan; Patel Anup; Bjartell Anders S.; Caris Christien; Schipper Raymond G.; Witjes Wim P. J.; Horstmann Joerg; Machtens Stefan; Mumperow Eberhard; Al Ghazal Andreas; Pulte Thomas; Stephan-Odenthal Michael; Gakis Georgios; Kramer Mario; Zaak Dirk; Schmitz-Draeger Bernd; Schreier Holger; Lehmann Jan; Werner Torsten; Klier Joerg; Marin Jan; Rulf Wolfgang; Hellmis Eva; Schneider Andreas; Spiegelhalder; Wirth Manfred; Klotz Theodor; Suttmann Henrik; Siebels Michael; Rodemer Gerd; Rudolph Robert; Zillmann Roger; de Bruin M.; Bos S.; van Moorselaar R.; de Reijke T.; Boormans J.; Wijsman B.; van Melick H. H. E.; van Boven E.; Meijer R. P.; van der Heijden A. G.; Vergunst H.; te Slaa E.; Leliveld-Kors A. M.; Ruffion Alain; Pfister Christian; Roupret Morgan; Irani Jacques; Stoica Gabriel; Van Bruwaene Siska; Ameye Filip; Arentsen Harm; Joniau Steven; Beardo Pastora;
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作者单位

Jena Univ Hosp Dept Urol Klinikum 1 D-07747 Jena Germany;

Radboud UMC Dept Urol Nijmegen Netherlands;

Hosp Edouard Herriot Dept Urol Lyon France;

Univ Hosp Leuven Dept Urol Leuven Belgium;

Hosp Univ La Paz Dept Urol Madrid Spain;

Charles Univ Prague Hosp Motol Dept Urol Prague Czech Republic;

Acibadem Univ Dept Urol Istanbul Turkey;

Fundacio Puigvert Urol Dept Barcelona Spain;

EAU Res Fdn Arnhem Netherlands;

EAU Res Fdn Arnhem Netherlands;

EAU Res Fdn Arnhem Netherlands;

EAU Res Fdn Arnhem Netherlands;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Bacillus Calmette-Guerin; Instillation therapy; Non-muscle-invasive bladder cancer; Reduced frequency;

机译：Bacillus Calmette-guerin;滴注治疗;非肌肉侵入性膀胱癌;减少频率;

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外文文献

1. Reduced dose of Bacillus Calmette-Guérin versus full dose of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer after transurethral resection bladder tumor: a meta-analysis of randomized controlled trials [J] . Qin Xin, Wu Keming, Xie Libo, 中华医学杂志（英文版） . 2014,第022期
2. Re: Long-Term Outcome of Patients with Frequently Recurrent Non-Muscle-Invasive Bladder Carcinoma Treated with One Perioperative plus Four Weekly Instillations of Mitomycin C followed by Monthly bacillus Calmette-Guerin ( BCG) or Alternating BCG and Interferon-alpha 2b Instillations: Prospective Randomised FinnBladder-4 Study [J] . Chang Sam S. The Journal of Urology . 2017,第3aPta1期

机译：Re：用一个围手术期加上四个每周霉菌菌素C的患者的长期结果常见的非肌肉侵入性膀胱癌，随后是每月芽孢菌植物霉素（BCG）或交替的BCG和干扰素-α2B滴注：前瞻性随机化的Finnbladder-4研究
3. Long-term Outcome of Patients with Frequently Recurrent Non-muscle-invasive Bladder Carcinoma Treated with One Perioperative Plus Four Weekly Instillations of Mitomycin C Followed by Monthly Bacillus Calmette-Guerin (BCG) or Alternating BCG and Interferon-alpha 2b Instillations: Prospective Randomised FinnBladder-4 Study [J] . Jarvinen Riikka, Marttila Timo, Kaasinen Eero, European urology . 2015,第4期

机译：一次围手术期加丝裂霉素C每周四次滴注丝裂霉素-Cerin-Guerin（BCG）或交替BCG和干扰素-α2b滴注的围手术期加每周四次滴注治疗的复发性非肌肉侵犯性膀胱癌患者的长期结果：前瞻性随机FinnBladder -4学习
4. Side effects of bacillus calmette-guérin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: Results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose and 1 year with 3 years of maintenance BCG [J] . BrausiM., OddensJ., SylvesterR., European urology . 2014,第1期

机译：卡介苗（BCG）在治疗中，高危Ta，T1膀胱乳头状癌中的副作用：EORTC生殖泌尿系统癌症小组的3期随机研究比较了三分之一剂量和全剂量和1年加3年BCG维护
5. Background and Update for S1602 A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-naïve High-grade Non-muscle-invasive Bladder Cancer [O] . Robert S. Svatek, Cathy Tangen, Scott Delacroix, -1

机译：S1602 III期随机试验以评估BCG初治非高度侵袭性膀胱癌的膀胱内治疗之前用皮内BCG评估BCG株差异和T细胞启动的影响的背景和更新
6. Background and Update for S1602 “A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-naïve High-grade Non-muscle-invasive Bladder Cancer [O] . Robert S. Svatek, Cathy Tangen, Scott Delacroix, 2018

机译：S1602的背景和更新“A III期随机试验，以评估BCG菌株和T细胞引发与皮内BCG在BCG-Naïve高档非肌肉侵袭性膀胱癌中的膀胱内部BCG对C细胞引发的影响
7. Phase 3 Randomized Trial of Low Dose Versus Standard Dose m-BACOD Chemotherapy with rGM-CSF for Treatment of AIDS-Associated Non-Hodgkins Lymphona (ACTG 142) Documentation;Final rept [R] . 1995

机译：第3阶段低剂量随机试验与标准剂量m-BaCOD化疗联合rGm-CsF治疗艾滋病相关非霍奇金淋巴膜（aCTG 142）文献;最终报告

Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial 'NIMBUS'

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