Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

Nguyen Bastien; Mota Jose Mauricio; Nandakumar Subhiksha; Stopsack Konrad H.; Weg Emily; Rathkopf Dana; Morris Michael J.; Scher Howard I; Kantoff Philip W.; Gopalan Anuradha; Zamarin Dmitriy; Solit David B.; Schultz Nikolaus; Abida Wassim

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Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

机译：CDK12改变的泛癌分析鉴定了具有不同基因组和临床特征的前列腺癌的子集

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Background: CDK12 genomic alterations occur in several tumor types, but little is known about their oncogenic role and clinical significance.

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《European urology》 |2020年第5期|共9页
作者
Nguyen Bastien; Mota Jose Mauricio; Nandakumar Subhiksha; Stopsack Konrad H.; Weg Emily; Rathkopf Dana; Morris Michael J.; Scher Howard I; Kantoff Philip W.; Gopalan Anuradha; Zamarin Dmitriy; Solit David B.; Schultz Nikolaus; Abida Wassim;
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作者单位

Mem Sloan Kettering Canc Ctr Marie Josee &

Henry R Kravis Ctr Mol Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Med Genitourinary Oncol Serv 1275 York Ave New York NY 10065;

Mem Sloan Kettering Canc Ctr Marie Josee &

Henry R Kravis Ctr Mol Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Med New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Radiat Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Med Genitourinary Oncol Serv 1275 York Ave New York NY 10065;

Mem Sloan Kettering Canc Ctr Dept Med Genitourinary Oncol Serv 1275 York Ave New York NY 10065;

Mem Sloan Kettering Canc Ctr Dept Med Genitourinary Oncol Serv 1275 York Ave New York NY 10065;

Mem Sloan Kettering Canc Ctr Dept Med New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Pathol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Med Gynecol Med Oncol Serv New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Marie Josee &

Henry R Kravis Ctr Mol Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Marie Josee &

Henry R Kravis Ctr Mol Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Dept Med Genitourinary Oncol Serv 1275 York Ave New York NY 10065;

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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
CDK12; Clinical sequencing; Genomics; Prostate cancer; Tumor biology;

机译：CDK12;临床测序;基因组学;前列腺癌;肿瘤生物学;

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1. The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing [J] . Alexander W Wyatt, Fan Mo, Yuzhuo Wang, 亚洲男性学杂志（英文版） . 2013,第003期
2. RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions,cancer-associated long noncoding RNAs and aberrant alternative splicings [J] . Shancheng Ren, Weidong Xu, Chao Chen, 细胞研究（英文版） . 2012,第005期
3. DNA alterations in the tumor genome and their associations with clinical outcome in prostate cancer [J] . Wennuan Liu 亚洲男性学杂志（英文版） . 2016,第004期
4. Somatic DNA copy number alterations and their potential clinical utility for predicting lethal prostate cancer [J] . Wennuan Liu, Li Wang, Jianfeng Xu 亚洲男性学杂志（英文版） . 2013,第005期
5. Pan-Cancer Analysis of CDK12 Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype [J] . Ethan S. Sokol, Emmanuel S. Antonarakis, Dean Pavlick, The oncologist . 2019,第12期

机译：CDK12函数丧失改变的泛癌分析及其与局灶性串联 - 重复仪表型的关联
6. Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics [J] . Goran Jonsson, Johan Staaf, Johan Vallon-Christersson, Breast Cancer Research . 2010,第3期

机译：通过阵列比较基因组杂交鉴定的乳腺癌基因组亚型表现出独特的分子和临床特征
7. CDK12 Gene Alterations in Prostate Cancer: Present but Clinically Actionable? [J] . Marciscano Ariel E., Barbieri Christopher E. European urology . 2020,第5期

机译：前列腺癌中的CDK12基因改变：目前但在临床上可行吗？
8. Single Cell Genomic Profiling of Circulating Tumor Cells (CTCs) from Metastatic Colorectal Cancer (mCRC) Identify Tumor Heterogeneity and Rare Somatic Driver Alterations [C] . Stephanie Greene, Angel Rodriguez, Jerry Lee, International Molecular Medicine Tri-Conference. . 2016

机译：转移结直肠癌（MCRC）的循环肿瘤细胞（CTC）的单细胞基因组分析识别肿瘤异质性和稀有躯体驾驶员改变
9. Integrating genomics and molecular biology: identifying transcriptional targets for the prostate cancer oncogene SOX4 and evaluating the efficacy of Aurora kinase inhibition in chemotherapy-resistant ovarian cancer [D] . Scharer, Christopher D. 2009

机译：整合基因组学和分子生物学：鉴定前列腺癌致癌基因SOX4的转录靶标并评估Aurora激酶抑制作用对化疗耐药的卵巢癌的疗效
10. Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics [O] . Göran Jönsson, Johan Staaf, Johan Vallon-Christersson, 2010

机译：通过阵列比较基因组杂交鉴定的乳腺癌基因组亚型表现出独特的分子和临床特征
11. Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics [O] . Jönsson, Göran B, Staaf, Johan, Vallon-Christersson, Johan, 2010

机译：通过阵列比较基因组杂交鉴定的乳腺癌的基因组亚型显示出不同的分子和临床特征
12. Unique Genomic Alterations in Prostate Cancers in African American Men [R] . Ittmann, M 2014

机译：非洲裔美国男性前列腺癌的独特基因组改变

Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

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