Optimal management of DRESS syndrome in course of infectious endocarditis

摘要

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a life-threatening adverse reaction characterized by a delayed onset after therapy initiation (usually 2-4 weeks), eosinophilic organ damage, and a paradoxical worsening of symptoms after discontinuation of the causative drug. DRESS syndrome patho-genesis implies different potential mechanisms, including detoxification defects leading to drug metabolite formation, slow acetylation processes, and reactivation of human herpes viruses.