Polyethylene glycols (macrogols) are condensation products of glycols with ethylene oxide and are widely used as excipients in food, cosmetics, and topical and systemic drugs because of their stabilizing properties. Although macrogols are used frequently and extensively, only a few immediate hypersensitivity reactions have been reported, probably because they are poorly absorbed by the gastrointestinal tract. Immediate hypersensitivity reactions have been reported after parenteral and oral administration of products containing macrogols, such as cortico-steroids, laxative oral solutions, and tablets. We report the first case, to our knowledge, of a positive basophil activation test result after exposure to macrogol in a patient who reported systemic reactions after the oral intake of 2 different drugs in 2 different pharmaceutical preparations (granules and syrup) containing macrogols 4,000 and 6,000.
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