Inversion Recovery Susceptibility Weighted Imaging With Enhanced T-2 Weighting at 3 T Improves Visualization of Subpial Cortical Multiple Sclerosis Lesions

摘要

Objectives Cortical demyelination is common in multiple sclerosis (MS) and can be extensive. Cortical lesions contribute to disability independently from white matter lesions and may form via a distinct mechanism. However, current magnetic resonance imaging methods at 3 T are insensitive to cortical, and especially subpial cortical, lesions. Subpial lesions are well seen on T-2*-weighted imaging at 7 T, but T-2*-weighted methods on 3 T scanners are limited by poor lesion-to-cortex and cerebrospinal fluid-to-lesion contrast. We aimed to develop and evaluate a cerebrospinal fluid-suppressed, T-2*-weighted sequence optimized for subpial cortical lesion visualization.