Potassium alum as a naturally mineral and economical catalyst for the one-pot, multi-component and clean synthesis of 2-oxo(thio)-1,2,3,4-teirahydropyrimidines and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates

摘要

An environmental friendly synthetic route for potassium alum catalyzed one-pot multi-component synthesis of biologically active 2-oxo(thio)-1,2,3,4-tetrahydropyrimidines and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates has developed. The present synthetic route has the notable advantages of natural, mineral, inexpensive and non-toxic catalyst, mild reaction conditions, eco-friendly, one-pot and good to high yield of biological active products. This method is simple for work up and the compound formed filtered and purified just by simple crystallization.