In vitro and Molecular Docking Studies of DPPH with Phoenix dactylifera L. (Deglet-Nour) Crude Fruits extracts and Evaluation of their Antioxidant Activity

摘要

Uses edible parts of date palm {Phoenix dactylifera L) fruits from Algeria were analyzed to determine their phenolic compound and antioxidant activities using DPPH, FRAP assay and molecular docking. In this paper, in-silico and in-vitro studies were used to study interaction Enzyme-Compounds and evaluate antioxidant activities of compounds. The results show that the date fruit rich in the total phenolic content was found Gallic acid, the flavonoid: quercetin and condensed tannins of catechin. The antioxidant activity ranged between 64, 46-91, 3 for DPPH (%) and 0,194-14,923ug AAE/ 0.5mg extract for FRAP. In-silico analysis was an agreement with in-vitro in which phenolic compounds showed more negative free energy against standard drug and bound with catalytic residues of Kinase. The findings provide evidence that date fruit has potential as a natural source of antioxidant with ethyl acetate showing to be the best extracting with corresponding higher antioxidant activities.