DIABETIC MANAGEMENT POTENTIAL OF PTEROCARPUS MARSUPIUM ROXB. ON MSG OBESE ALBINO MOUSE,MUS MUSCULUS

摘要

Obesity is a complex multifactor problem characterized by the excessive accumulation of adipose tissue. This increase leads to a disturbance in the general metabolic state and results in a number of clinical diseases such as non-insulin dependent Diabetes mellitus, cardiovascular disease, hyperlipidemia and hypertension. In this study, the MSG diabetic mice (Induced by Monosodium glutamate) gained nearly 65% of its body weight during the 60 days of the experiment and the control mice gained only 29.5% of its body weight. The MSG injected animals also showed a higher Lee index. The treatment with the P. marsupium distillate for 60 days had aided the diabetic mouse to regulate its blood glucose permanently. The treatment of the MSG diabetic mice withthe heartwood of the P.marsupium crude extract had resulted in 66% of mortality in 120 days. The findings from the physiological, histological, endocrinological and molecular studies of this work had proved the antidiabetic potential of P. marsupium in MSG obese mice. At the same time, it was also clear that the crude extract, though it possesses a strong antidiabetic potential, had a deleterious effect in the MSG mice.