Trimethyltin chloride determination by hydride generation-gas phase molecular absorption spectrometry A sequential application of experimental designs

摘要

In this paper, a sequential experimental design is applied to optimize the determination of trimethyltin chloride (TMT) by hydride generatiion-gas phase molecular absorption spectrometry. The TMT is converted into gaseous trimethyltin hydride by adding a sodium tetrahydroborate (III) solution. The hydride generated is collected in a liquid nitrogen cryogenic trap. This is revolatilized, driven to the quartz flow cell and measured with gas phase molecular absorption spectrometry with diode array detection. A Plackett-Burman design is used to study the parameters affecting the production, collection and measurement of the hydrides. The optimization of these parameters is achieved using a central composite design. PLS. MLR and univariate calibration are applied ot the spectra obtained. The detection and quantification limits are 1.5 adn 4.6 ng ml~(-1), respectively, and the relative standard deviation (n=10) at 15 ng ml~(-1) was 5.5%. An interference study is presented.