Stabilization of Delphinidin in Complex with Sulfobutylether-beta-Cyclodextrin Allows for Antinociception in Inflammatory Pain

Sauer Reine-Solange; Krummenacher Ivo; Bankoglu Ezgi Eylul; Yang Shaobing; Oehler Beatrice; Schoeppler Friedrich; Mohammadi Milad; Guentzel Paul; Ben-Kraiem Adel; Holzgrabe Ulrike; Stopper Helga; Broscheit Jens A.; Braunschweig Holger; Roewer Norbert; Brack Alexander; Rittner Heike L.

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Stabilization of Delphinidin in Complex with Sulfobutylether-beta-Cyclodextrin Allows for Antinociception in Inflammatory Pain

机译：与磺基丁基 - β-环糊精络合物中玻璃蛋白的稳定允许在炎性疼痛中进行抗闭合症

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摘要

Aims: Delphinidin (DEL) is a plant-derived antioxidant with clinical potential to treat inflammatory pain but suffers from poor solubility and low bioavailability. The aim of the study was to develop a well-tolerated cyclodextrin (CD)-DEL complex with enhanced bioavailability and to investigate the mechanisms behind its antinociceptive effects in a preclinical model of inflammatory pain.

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来源
《Antioxidants and redox signalling》 |2021年第16期|共20页
作者
Sauer Reine-Solange; Krummenacher Ivo; Bankoglu Ezgi Eylul; Yang Shaobing; Oehler Beatrice; Schoeppler Friedrich; Mohammadi Milad; Guentzel Paul; Ben-Kraiem Adel; Holzgrabe Ulrike; Stopper Helga; Broscheit Jens A.; Braunschweig Holger; Roewer Norbert; Brack Alexander; Rittner Heike L.;
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作者单位

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Julius Maximilians Univ Wurzburg Inst Inorgan Chem Wurzburg Germany;

Julius Maximilians Univ Wurzburg Inst Pharmacol &

Toxicol Wurzburg Germany;

Huazhong Univ Sci &

Technol Tongji Hosp Dept Anesthesiol &

Pain Med Tongji Med Coll Wuhan;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Julius Maximilians Univ Wurzburg Inst Phys &

Theoret Chem Wurzburg Germany;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Julius Maximilians Univ Wurzburg Inst Pharm &

Food Chem Wurzburg Germany;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Julius Maximilians Univ Wurzburg Inst Pharm &

Food Chem Wurzburg Germany;

Julius Maximilians Univ Wurzburg Inst Pharmacol &

Toxicol Wurzburg Germany;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Julius Maximilians Univ Wurzburg Inst Inorgan Chem Wurzburg Germany;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

Univ Hosp Wurzburg Dept Anesthesiol Ctr Interdisciplinary Pain Med Oberdurrbacher Str 6 D-97080;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
delphinidin; cyclodextrins; pain; ROS; 4-HNE; antinociception;

机译：Delphinidin;环糊精;疼痛;ROS;4-HNE;抗休养液;

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9. Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain [O] . Steve McGaraughty, Prisca Honore, Carol T Wismer, 2005

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10. Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain [O] . McGaraughty, Steve, Honore, Prisca, Wismer, Carol T, 2009

机译：内源性阿片类物质机制在炎症性和化学性疼痛的大鼠模型中部分介导P2X3 / P2X2 / 3相关的镇痛作用，但在神经性疼痛中不起作用
11. VIPER: Chronic Pain after Amputation: Inflammatory Mechanisms, Novel Analgesic Pathways, and Improved Patient Safety. [R] . Van de Ven, T. 2017

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Stabilization of Delphinidin in Complex with Sulfobutylether-beta-Cyclodextrin Allows for Antinociception in Inflammatory Pain

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