A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance

Tu Thomas; Zehnder Benno; Qu Bingqian; Ni Yi; Main Nathan; Allweiss Lena; Dandri Maura; Shackel Nicholas; George Jacob; Urban Stephan

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A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance

机译：一种新的方法，精确地量化乙型肝炎病毒共价封闭圆形（CCC）DNA形成和维护

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Hepatitis B virus (HBV) is the major cause of virus-associated liver disease. Persistent HBV infection is maintained by its episomal genome (covalently closed circular DNA, cccDNA), which acts as a template for viral transcripts. The formation of cccDNA is poorly characterised due to limited ability to quantify it accurately in the presence of replicative intermediates.

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来源
《Antiviral Research》 |2020年第1期|共10页
作者
Tu Thomas; Zehnder Benno; Qu Bingqian; Ni Yi; Main Nathan; Allweiss Lena; Dandri Maura; Shackel Nicholas; George Jacob; Urban Stephan;
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作者单位

Univ Hosp Heidelberg Dept Infect Dis Mol Virol Heidelberg Germany;

Univ Hosp Heidelberg Dept Infect Dis Mol Virol Heidelberg Germany;

Univ Hosp Heidelberg Dept Infect Dis Mol Virol Heidelberg Germany;

Univ Hosp Heidelberg Dept Infect Dis Mol Virol Heidelberg Germany;

Ingham Inst Appl Med Res Gastroenterol &

Liver Lab Sydney NSW Australia;

Univ Med Ctr Hamburg Eppendorf Dept Internal Med Ctr Internal Med Hamburg Germany;

Univ Med Ctr Hamburg Eppendorf Dept Internal Med Ctr Internal Med Hamburg Germany;

Ingham Inst Appl Med Res Gastroenterol &

Liver Lab Sydney NSW Australia;

Westmead Hosp Westmead Inst Med Res Storr Liver Ctr Westmead NSW Australia;

Univ Hosp Heidelberg Dept Infect Dis Mol Virol Heidelberg Germany;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
Covalently closed circular DNA; Hepatitis B virus; Viral persistence; Humanised mice; Myrcludex B; Hepcludex; Bulevirtide; cinqPCR; DNA nick; DNA repair;

机译：共价闭合的圆形DNA;乙型肝炎病毒;病毒持久性;人源化老鼠;Myrcludex B;Hepcludex;Bulevixtide;CinqPCR;DNA昵称;DNA修复;

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专利

1. Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection [J] . Zhaoning Wang, Weiwei Wang, Lanfeng Wang 生物物理学报：英文版 . 2020,第004期
2. Exonuclease Ⅰ and Ⅲ improve the detection efficacy of hepatitis B virus covalently closed circular DNA [J] . Pei-Xue Jiang, Ri-Cheng Mao, Min-Hui Dong, 国际肝胆胰疾病杂志（英文版） . 2019,第005期
3. Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays. [J] . Zhou T, Guo H, Guo JT, Antiviral Research . 2006,第2期

机译：乙型肝炎病毒e抗原的产生取决于HepAD38细胞培养物中的共价闭合环状（ccc）DNA，并且可以作为抗病毒筛选测定中的cccDNA替代物。
4. Hepatitis B Virus e Antigen Production is Dependent upon Covalently Closed Circular (ccc) DNA in HepAD38 Cell and May Serve as a cccDNA Surrogate in Antiviral Screening Assays [J] . Haitao Guo, Tianlun Zhou, Ju-tao Guo, Antiviral Research . 2006,第1期

机译：乙型肝炎病毒e抗原的产生取决于HepAD38细胞中的共价闭合环状（ccc）DNA，在抗病毒筛选测定中可能作为cccDNA替代品
5. PP-008 Quantification of hepatitis B virus total DNA and covalently closed circular DNA in cirrhosis of hepatitis B patients' serum and liver biopsies [J] . Y.Li, T.Han International journal of infectious diseases : . 2008,第Supplementa3期

机译：PP-008乙型肝炎患者血清和肝活检肝硬化中乙型肝炎病毒总DNA和共价闭合环状DNA的定量
6. Simultaneous Quantification for Hepatitis B Virus and Hepatitis C Virus Using Real-time PCR Lab-on-a-chip [C] . Institute of Electrical and Electronics Engineers International Conference on Nano/Micro Engineered and Molecular Systems . 2006

机译：使用实时PCR实验室芯片同时定量乙型肝炎病毒和丙型肝炎病毒
7. Novel Methods for Specific Detection and Quantification of Covalently Closed Circular DNA in Sera and Biopsies of Hepatitis B Patients. [D] . Yu, Ling. 2011

机译：特异性检测和定量乙肝患者血清和活检中共价闭合环状DNA的新方法。
8. Identification of an Intermediate in Hepatitis B Virus Covalently Closed Circular (CCC) DNA Formation and Sensitive and Selective CCC DNA Detection [O] . Jun Luo, Xiuji Cui, Lu Gao, 2017

机译：鉴定乙型肝炎病毒共价闭合环状（CCC）DNA形成的中间体以及敏感和选择性的CCC DNA检测
9. PP-008 Quantification of hepatitis B virus total DNA and covalently closed circular DNA in cirrhosis of hepatitis B patients' serum and liver biopsies [O] . Li Y., Han T. 2008

机译：PP-008乙型肝炎患者血清和肝活检肝硬化中乙型肝炎病毒总DNA和共价闭合环状DNA的定量
10. Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA. [R] . Sjogren, M. H., Dusheiko, G. M., Kew, M. C., 1988

机译：乙型肝炎病毒感染和肝细胞癌：乙型肝炎核心抗原，乙型肝炎抗原和乙型肝炎DNa的Igm抗体之间的相关性。

A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance

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