A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3-H2O2 system

摘要

In this work, an Fe3O4 nanoparticles (NPs)-enhanced chemiluminescence (CL) method was developed for the determination of verapamil hydrochloride (VRP). To this aim, a quick precipitation method was employed to synthesize Fe3O4 NPs. The synthesised Fe3O4 NPs were then characterized by using techniques including Fourier Transform Infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). It was found that the Fe3O4 NPs were able to enhance the NaHCO3-H2O2 CL reaction. In addition, it was shown that VRP had an inhibitory effect on the Fe3O4 NPs-NaHCO3-H2O2 system in such a way that the CL intensity was inversely proportional to the concentration of VRP. These findings were used for the establishment of a new, green, simple and sensitive CL analytical method for VRP with a linear dynamic range of 5.0 x 10(-6) to 1.0 x 10(-3) mol L-1, a correlation coefficient (r(2)) of 0.99 and a limit of detection of 2.8 x 10(-6) mol L-1. The CL methodwas successfully used for the determination of VRP in pharmaceutical formulations.