Differential NFATc1 Expression in Primary Cutaneous CD4(+) Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma

摘要

Background: Primary cutaneous CD4(+) small/medium-sized pleomorphic T-cell lymphoma (PCSTCL) has recently emerged as a distinct clinicopathological entity. Because of a considerable degree of overlap with pseudolymphoma, the diagnosis is often challenging. Preliminary studies suggest that nuclear upregulation of calcineurin/ nuclear factor of activated T cells (NFAT) may play a role in lymphomagenesis.