Nanoparticle Albumin-bound Paclitaxel Plus Carboplatin Induction Followed by Nanoparticle Albumin-bound Paclitaxel Maintenance in Squamous Non-Small-cell Lung Cancer ABOUND.sqm): A Phase III Randomized Clinical Trial

摘要

Prospective randomized studies of maintenance therapy for patients with squamous non-small-cell lung cancer are lacking. In the present study, patients without disease progression after induction treatment were randomized 2:1 to maintenance nanoparticle albumin-bound paclitaxel plus best supportive care or best supportive care alone. The primary endpoint (progression-free survival) was not met. Given the current treatment paradigm, these findings can be expected to minimally affect treatment practice.