Capillary gas chromatographic properties of three new cyclodextrin derivatives with acyl groups in the 6-position of beta-cyclodextrin

摘要

Three cyclodextrin derivatives(CDs)were synthesized by substituting different acyl groups(valeryl,heptanoyl,and octanoyl)in the 6-position of 2,3-di-O-pentyl-beta-cyclodextrin.The chromatographic properties of the three CDs as capillary gas chromatographic stationary phases were investigated.It is found that the carbon chain length of acyl groups in the 6-position of the CDs has some effects on their enantioseparation abilities.Among the three cyclodextrin derivatives,2,3-di-O-pentyl-6-O-valeryl-beta-cyclodextrin possesses the best enantioselectivity to 15 pairs of enantiomers studied.The enantioseparation results are relate to both the structure of cyclodextrin derivatives and the structure of solutes.