Fully automated drug liberation apparatus for semisolid preparations based on sequential injection analysis

摘要

A novel set-up of a fully automated system based of the SIA technique connected to the liberation apparatus,Franz cell,is described.The SIA system was applied to observe different membrane materials (poly-carbonate,mixed esters of cellulose,Teflon,silicon,poly-vinylidene fluorirde,etc.)and used for monitoring liberation profiles of Indomethacin 1% gel.comparison of the liberation rates of gels and ointment prepared by different technological procedures was demonstrated.Liberation medium was 0.001 M NaOH;samples were taken in 10 min intervals during 6 h of the liberation test;and each test was followed by calibration with five standard solutions.The linear calibration rage was 0.05-10 mg l~(-1)(r=0.9998,six standards);the samle throughput was 120 h~(-1),sample volume being 50 mul and flow rate 50 mul s~(-1).The detection limit for indomethacin determination was 0.04 mg l~(-1)(3signa).The optimisedconditions were also used for indomethacin assay in topic formulaton Indomethacin gel 1%.Results obtained with the SIA system were confirmed by conventional batch UV measurement.