The relationship between childhood trauma, early-life stress, and alcohol and drug use, abuse, and addiction: An integrative review

摘要

In this review, we discuss the relationship between childhood trauma, early-life stress, and substance use, abuse, and addiction. We further provide theories and neural studies to explain this relationship as well as potential treatment strategies for alcohol and drug abuse and addiction based on understanding types of early-life stressors that lead to both drug use and relapse.