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首页> 外文期刊>Analytica chimica acta >Flow injection chemiluminescence determination of cephalosporins in pharmaceutical preparations using tris(2,2'-bipyridyl)ruthenium (II)-potassium permanganate system
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Flow injection chemiluminescence determination of cephalosporins in pharmaceutical preparations using tris(2,2'-bipyridyl)ruthenium (II)-potassium permanganate system

机译:三(2,2'-联吡啶)钌(II)-高锰酸钾体系流动注射化学发光法测定药物制剂中的头孢菌素

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摘要

A flow injection(FT)method using the tris(2,2'-bipyridyl)ruthenium(II)[Ru(bpy)_3~(2+)]-potassium permanganate chemiluminescence(CL)was developed for the rapid and sensitive determination of cephalosporins such as cefoxitin,cefazolin,cephalexin,cefadroxil,cefaclor and cefoperazone.The method is based on the CL reaction of cephalosporins and Ru(bpy)_3~(2+)with potassium permanganate in the presence of perchloric acid,catalyzed by Mn(II).Under the optimum conditions,the calibration curves are linear over the range 0.10-12.0 mugml~(-1)for cefoxitin,0.10-10.0 mugml~(-1)for cefoperazone and 0.10-15.0 mug ml~(-1)for cefazolin,cephalexin,cefadroxil,and cefaclor,respectively.The limits of detection(3sigma)are 0.03 mug ml~(-1)for cefoxitin and cefadroxil,0.06 mug ml~(-1)for cefoperazone and 0.08 mug ml~(-1)for cefazolin,cephalexin and cefaclor,respectively.The method was successfully applied to the determination of cefoxitin,cefazolin,cephalexin and cefadroxil in pharmaceutical formulations with a sample throughput of 90 h~(-1).There were no interference effects from some common excipients used in pharmaceutical preparations.
机译:开发了使用三(2,2'-联吡啶基)钌(II)[Ru(bpy)_3〜(2 +)]-高锰酸钾化学发光(CL)的流动注射(FT)方法,用于快速,灵敏地测定头孢菌素,如头孢西丁,头孢唑啉,头孢氨苄,头孢曲氨酯,头孢克洛和头孢哌酮。该方法基于头孢菌素和Ru(bpy)_3〜(2+)与高锰酸钾在高氯酸存在下的CL反应,由Mn(Mn)催化。 II)。在最佳条件下,头孢西丁的校准曲线在0.10-12.0 mugml〜(-1),头孢哌酮0.10-10.0 mugml〜(-1)和0.10-15.0 cup ml〜(-1)范围内呈线性关系头孢唑林,头孢氨苄,头孢曲氨酯和头孢克洛的检出限分别为(3sigma)。对于头孢西丁和头孢克罗地尔的检出限为0.03毫升/毫升(-1),对于头孢哌酮为0.06毫升/毫升(-1)和0.08马克毫升〜(- 1)分别用于测定头孢唑啉,头孢氨苄和头孢克洛。该方法已成功地用于测定药物制剂中头孢西丁,头孢唑啉,头孢氨苄和头孢氨苄的含量。样品通量为90 h〜(-1)。药物制剂中使用的一些常见赋形剂没有干扰作用。

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