New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

摘要

Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu-2 (3-ClC6H4CH2COO)(4) (phen)(2)] (1) and [Cu-2(3-ClC6H4CH2COO)(4) (bipy)(2)] (2) where phen = 1,10-phenanthroline and bipy = 2,2'-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and single crystal XRD. The results revealed distorted square pyramidal geometry around each copper atom of 1 and 2. The DNA interaction studies showed strong binding with K-b = 5.07 x 10(3) and 4.62 x 10(3) M-1 for 1 and 2, respectively. Both complexes showed strong enzyme inhibition, i.e., 70% and 90% for alpha-glucosidase with IC50 = 34.6 and 30.1 mu M for 1 and 2, respectively, where acarbose was employed as control. However, both the complexes were found inactive against alpha-amylase. Using galantamine hydrobromide as control, 1 showed moderate inhibition activity (47%) with IC50 = 179.4 mu M for acetylcholine esterase whereas 2 showed strong inhibition activity (76%) with IC50 = 95.8 mu M for butyrylcholine esterase. The data reflects active anti-diabetic and anti-Alzheimer's nature of the synthesized complexes.