Electrochemical Behavior of Dopamine at a Mercury Electrode in the Presence of Citrate:Analytical Applications

摘要

Dopamine can be determined by voltammetric methods using a mercury electrode,previously oxidized at +0.30 V.The oxidation product formed is stabilized in the presence of citrate and undergoes reduction at - 0.31 V.This work describes the electrochemical behavior of dopamine at a mercury electrode in the presence of citrate and its application in the development of a square-wave voltammetric method for the dopamine determination in pharmaceutical formulations.The method was in-house validated for determination of dopamine in injectable formulations.The detectability of the method was 0.02 mu g ml~(-1).