Highly Sensitive Electrogenerated Chemiluminescence Isoniazid with NiO Nanoparticles-modified Graphite Electrode

摘要

NiO nanoparticles (NiO NPs) were prepared with chemical precipitation method and modified on the surface of vaseline-impregnated graphite electrode with chitosan.It was found that,based on the catalysis of the NiO NPs for the chemilumi-nescent reaction of the ECL process,the enhancing effect of isoniazid on the weak electrogenerated chemiluminescence (ECL) signal of luminol at a NiO NPs-chitosan modified electrode was stronger than that at a bare graphite electrode.Under the optimum experimental conditions,the relative ECL intensity was linear with isoniazid concentration over the range 3.0 x 10~(10)~1.0 x 10~(-6) g/ml at the NiO NPs-chitosan modified electrode with a detection limit of 1.0 x 10~(-10) g/ml.