Simultaneous Determination of Ibuprofen and Pseudoephedrine Hydrochloride in Pharmaceutical Tablets by Reversed-Phase HPLC

摘要

An isocratic HPLC method was developed and validated for the simultaneous determination of ibuprofen (IBU) and pseudoephedrine hydrochloride (PSE). Chromatography was carried out on an Apex phenyl column using 0.025M acetic acid, triethylamine solution (pH 4.5) – acetonitrile (80:20, v=v) as mobile phase at a flow rate of 1mL min1. UV detection was performed at a wavelength of 210 nm. The method was validated for specificity, linearity, accuracy, precision, and was successfully applied to pharmaceutical tablets of Rhinadvil.