Electroanalytical characterization of adenosine mono-, di- and triphosphate oxidation on carbon electrode

摘要

Electrochemical oxidation of adenosine mononucleotides was characterized using a pencil graphite carbon electrode for the first time. All three adenosine mononucleotides, adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP), showed irreversible electro-activity at the carbon electrode, yielding a well-defined oxidation current response. The peak potential was highly dependent on pH. The lowest mononucleotide concentration detected was 1 mu M. The electro-analytical data presented here for the oxidation of adenosine mononucleotides provides the basis for further bioanalytical investigations related to DNA-drug interactions.