Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

Araghi Sadaf Oliai; Kiefte-de Jong Jessica C.; van Dijk Suzanne C.; Swart Karin M. A.; Ploegmakers Kim J.; Zillikens M. Carola; van Schoor Natasja M.; de Groot Lisette C. P. G. M.; Lips Paul; Stricker Bruno H.; Uitterlinden Andre G.; van der Velde Nathalie

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Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

机译：叶酸和维生素-B12对骨折风险和心血管疾病进行补充的长期影响：延长了B样试验的延长后续

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Background & aims: In the initial B-proof, we found inconsistent results of B vitamin supplementation. However, the debate regarding the effects of B vitamins on age-related diseases continues. Therefore, our aim was to investigate the long-term effects (5-7 years follow-up) of an intervention with folic acid and vitamin-B12 supplementation on fracture and cardiovascular disease risk.

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来源
《Clinical nutrition》 |2021年第3期|共8页
作者
Araghi Sadaf Oliai; Kiefte-de Jong Jessica C.; van Dijk Suzanne C.; Swart Karin M. A.; Ploegmakers Kim J.; Zillikens M. Carola; van Schoor Natasja M.; de Groot Lisette C. P. G. M.; Lips Paul; Stricker Bruno H.; Uitterlinden Andre G.; van der Velde Nathalie;
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作者单位

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Erasmus MC Dept Epidemiol Rotterdam Netherlands;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Vrije Univ Amsterdam Amsterdam UMC Dept Gen Practice &

Elderly Care Med Amsterdam Publ Hlth Res;

Univ Amsterdam Amsterdam UMC Geriatr Med Sect Dept Internal Med Amsterdam Publ Hlth Res Inst;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Vrije Univ Amsterdam Amsterdam UMC Dept Epidemiol &

Biostat Amsterdam Publ Hlth Res Inst;

Wageningen Univ Div Human Nutr &

Hlth Wageningen Netherlands;

Vrije Univ Amsterdam Amsterdam UMC Dept Internal Med Endocrine Sect Amsterdam Publ Hlth Res Inst;

Erasmus MC Dept Epidemiol Rotterdam Netherlands;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类营养卫生、食品卫生;
关键词
B-vitamins; Fracture; Cardiovascular disease; Long-term follow-up;

机译：B-维生素;骨折;心血管疾病;长期随访;

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2. Effects of Maternal Folic Acid Supplementation on Hepatic Apoptosis- Related Gene Expressions between Intrauterine Growth Restriction and Normal Body Weight Piglets [J] . BingYu, JingboLiu, YingYao, 畜牧与生物技术杂志：英文版 . 2010,第002期
3. Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial [J] . Araghi Sadaf Oliai, Kiefte-de Jong Jessica C., van Dijk Suzanne C., Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2019,第2期

机译：叶酸和维生素B12补充和癌症的风险：预防骨质疏松骨折（B样）试验的B维生素的长期随访
4. Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial [J] . van Dijk Suzanne C., Enneman Anke W., Swart Karin M. A., Journal of hypertension . 2015,第9期

机译：在B-PROOF试验中，高同型半胱氨酸血症的老年人补充2年维生素B12和叶酸对动脉僵硬度和心血管结局的影响
5. Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial [J] . Taylor Caroline M., Atkinson Charlotte, Penfold Chris, Journal of Epidemiology & Community Health . 2015,第8期

机译：叶酸在怀孕中以及癌症和心血管疾病的死亡率：阿伯丁叶酸补充试验的进一步随访
6. Calcium supplementation and bone fragility fracturesduring growthA fracture risk assessment in a randomized controlled trial [C] . V. Matkovic, J.D. Landoll, N.E. Badenhop-Steven International Symposium on Nutritional Aspects of Osteoporosis . 2007

机译：随机对照试验中生长骨折风险评估期间的钙补充剂和骨脆性骨折
7. Anemia, motor development, and cognition: A randomized trial of iron-folic acid and/or zinc supplementation in young Nepali children. [D] . Siegel, Emily Hughes. 2005

机译：贫血，运动发育和认知：尼泊尔幼儿童补充铁叶酸和/或锌的随机试验。
8. Long-term Effect of Folic Acid and Vitamin B12 Supplementation on Fracture Risk and Cardiovascular Disease: Follow-up Study of B-PROOF Trial (P24-031-19) [O] . Sadaf Oliai Araghi, Jessica C Kiefte-de Jong, Suzanne van Dijk, 2019

机译：叶酸和维生素B12补充对骨折风险和心血管疾病的长期影响：B-PROOF试验的随访研究（P24-031-19）
9. Folic acid in pregnancy and mortality from cancer and cardiovascular disease : further follow-up of the Aberdeen folic acid supplementation trial [O] . Taylor, Caroline M, Atkinson, Charlotte, Penfold, Chris, 2015

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10. Framingham Study: An Epidemiological Investigation of Cardiovascular Disease. Section 38; the Relationship between Sporadically Measured Variables and the Risk of Cardiovascular Disease and Death; Framingham Heart Study, 30-34 Year Follow-Up [R] . Kannel, W. B. , Wolf, P. A. , Garrison, R. J. , 1988

机译：Framingham研究：心血管疾病的流行病学调查。第38条;零星测量变量与心血管疾病和死亡风险的关系;弗雷明汉心脏研究，30-34岁随访

Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

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