A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

Deniger Drew C.; Kwong Mei Li M.; Pasetto Anna; Dudley Mark E.; Wunderlich John R.; Langhan Michelle M.; Lee Chyi-Chia Richard; Rosenberg Steven A.

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A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

机译：vemurafenib与养殖黑素瘤患者采用养殖细胞疗法的试验试验试验

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Purpose: This pilot feasibility clinical trial evaluated the coad-ministration of vemurafenib, a small-molecule antagonist of BRAFV(600) mutations, and tumor-infiltrating lymphocytes (TIL) for the treatment of metastatic melanoma.

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2017年第2期|共12页
作者
Deniger Drew C.; Kwong Mei Li M.; Pasetto Anna; Dudley Mark E.; Wunderlich John R.; Langhan Michelle M.; Lee Chyi-Chia Richard; Rosenberg Steven A.;
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Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

Novartis Cell &

Gene Therapy Cambridge MA USA;

Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

Natl Canc Inst Natl Inst Hlth Pathol Lab Bethesda MD USA;

Ctr Canc Res Natl Canc Inst Natl Inst Hlth Surg Branch Bldg 10-CRC Room 3W-3940 10 Ctr Dr MSC;

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正文语种 eng
中图分类肿瘤学;
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1. Toxic epidermal necrolysis related to AP (pemetrexed plus cisplatin) and gefitinib combination therapy in a patient with metastatic non-small cell lung cancer [J] . Ji-Jie Huang, Shu-Xiang Ma, Xue Hou, 癌症（英文版） . 2015,第002期
2. Efficacy of capecitabine-based combination therapy and single-agent capecitabine maintenance therapy in patients with metastatic breast cancer [J] . Huimin Lv, Min Yan, Mengwei Zhang, 中国癌症研究（英文版） . 2014,第006期
3. Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial [J] . Grob Jean Jacques, Amonkar Mayur M., Karaszewska Boguslawa, The lancet oncology . 2015,第13期

机译：达拉非尼和曲美替尼联合疗法与维拉非尼单一疗法对无法切除或转移性皮肤BRAF Val600突变阳性黑色素瘤（COMBI-v）患者健康相关生活质量的比较：一项三阶段，开放标签，随机试验
4. T cell therapy in combination with Vemurafenib in BRAF mutated metastatic melanoma patients [J] . Troels Holz Borch, Rikke Andersen, Per Kongsted, Journal for ImmunoTherapy of Cancer . 2014,第S3期

机译：T细胞疗法联合维拉非尼治疗BRAF突变的转移性黑色素瘤患者
5. Combination of Ipilimumab and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma [J] . John E. Mullinax, MacLean Hall, Sangeetha Prabhakaran, Frontiers in Oncology . 2018,第1期

机译：伊匹木单抗联合过继性细胞治疗与肿瘤浸润淋巴细胞治疗转移性黑色素瘤患者
6. Cytotoxic T-cell induction in metastatic melanoma patients undergoing recombinant vaccinia virus-based immuno-gene therapy. [C] . Spagnoli GC, Zajac P, Marti WR, World Congress on Cancers of the Skin . 2002

机译：细胞毒性T细胞诱导在经历重组疫苗病毒的免疫基因治疗中的转移性黑素瘤患者。
7. Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma [D] . Soto, Carolina. 2012

机译：使用具有基因工程T细胞受体的原代T淋巴细胞针对黑素瘤和神经胶质瘤的过继细胞疗法
8. A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma [O] . Drew C. Deniger, Mei Li M. Kwong, Anna Pasetto, -1

机译：维拉非尼联合过继细胞治疗转移性黑色素瘤患者的初步试验
9. T cell therapy in combination with Vemurafenib in BRAF mutated metastatic melanoma patients [O] . Troels Borch, Rikke Andersen, Per Kongsted, 2014

机译：T细胞疗法联合维拉非尼治疗BRAF突变的转移性黑色素瘤患者
10. Effect of Metformin and Standard Therapy Versus Standard Therapy Alone in Nondiabetic Patients with Insulin Resistance and Nonalcoholic Steatohepatitis (NASH): A Pilot Trial [R] . Shields, W. W., Thompson, K. E., Grice, G. A., 2009

机译：二甲双胍和标准治疗与标准治疗对胰岛素抵抗和非酒精性脂肪性肝炎（NasH）非糖尿病患者单独使用的影响：试验

A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

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