Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma

Chicard Mathieu; Colmet-Daage Leo; Clement Nathalie; Danzon Adrien; Bohec Mylene; Bernard Virginie; Baulande Sylvain; Bellini Angela; Deveau Paul; Pierron Gaelle; Lapouble Eve; Janoueix-Lerosey Isabelle; Peuchmaur Michel; Corradini Nadege; Defachelles Anne Sophie; Valteau-Couanet Dominique; Michon Jean; Combaret Valerie; Delattre Olivier; Schleiermacher Gudrun

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Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma

机译：无细胞DNA的全末端测序显示出时间空间异质性，并鉴定神经母细胞瘤中的治疗克隆

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Purpose: Neuroblastoma displays important clinical and genetic heterogeneity, with emergence of new mutations at tumor progression.

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来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第4期|共11页
作者
Chicard Mathieu; Colmet-Daage Leo; Clement Nathalie; Danzon Adrien; Bohec Mylene; Bernard Virginie; Baulande Sylvain; Bellini Angela; Deveau Paul; Pierron Gaelle; Lapouble Eve; Janoueix-Lerosey Isabelle; Peuchmaur Michel; Corradini Nadege; Defachelles Anne Sophie; Valteau-Couanet Dominique; Michon Jean; Combaret Valerie; Delattre Olivier; Schleiermacher Gudrun;
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作者单位

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

PSL Res Univ Inst Curie SiRIC RTOP Rech Translat Oncol Pediat Translat Res Dept Res Ctr Paris;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

Inst Curie Inst Curie Genom Excellence ICGex Platform Res Ctr Paris France;

Inst Curie Inst Curie Genom Excellence ICGex Platform Res Ctr Paris France;

Inst Curie Inst Curie Genom Excellence ICGex Platform Res Ctr Paris France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

Inst Curie Hosp Grp Unite Genet Somat Serv Genet Paris France;

Inst Curie Hosp Grp Unite Genet Somat Serv Genet Paris France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

Hop Robert Debre APHP Serv Pathol Paris France;

Ctr Leon Berard Inst Hematol &

Oncol Pediat Lyon France;

Ctr Oscar Lambret Serv Oncol Pediat Lille France;

Inst Gustave Roussy Dept Pediat Oncol Villejuif France;

Inst Curie Dept Pediat Oncol Hosp Grp Paris France;

Ctr Leon Berard Plateforme Genom Canc Lyon France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

PSL Res Univ Inst Curie INSERM U830 Lab Genet &

Biol Canc Res Ctr Paris France;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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2. Whole-Exome Sequencing Identifies Origin of Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Case Report [J] . SHU Qing Ming, CHEN Xin Guo, ZHANG Hong Ying, 生物医学与环境科学（英文版） . 2020,第007期
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6. Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma [J] . Chicard Mathieu, Colmet-Daage Leo, Clement Nathalie, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第4期

机译：无细胞DNA的全外序列序列显示出时间空间异质性，并鉴定神经母细胞瘤中的治疗克隆
7. Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors [J] . Viktor A. Adalsteinsson, Gavin Ha, Samuel S. Freeman, Nature Communications . 2017,第1期

机译：无细胞DNA的可扩展全基因组测序揭示了与转移性肿瘤的高度一致性
8. Comprehensive analysis of tumoral DNA content reveals clonal ploidy heterogeneity as a marker with prognostic significance in locoregional neuroblastoma. [J] . Mora J, Lavarino C, Alaminos M, Genes, Chromosomes and Cancer . 2007,第4期

机译：肿瘤DNA含量的综合分析表明，克隆倍性异质性是局部区域神经母细胞瘤具有预后意义的标志。
9. A Bioinformatics Procedure to Identify and Annotate Somatic Mutations in Whole-Exome Sequencing Data [C] . Roberta Spinelli, Rocco Piazza, Alessandra Pirola, International meeting on computational intelligence methods for bioinformatics and biostatistics . 2012

机译：在整个外显子组测序数据中识别和注释体细胞突变的生物信息学程序
10. Analysis of somatic mutations identified by whole-exome sequencing in colorectal cancer metastasis [D] . Zhao, Bixiao 2016

机译：通过全外显子测序鉴定的大肠癌转移中的体细胞突变分析
11. Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors [O] . Viktor A. Adalsteinsson, Gavin Ha, Samuel S. Freeman, -1

机译：无细胞DNA的可扩展全基因组测序揭示了与转移性肿瘤的高度一致性
12. Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors [O] . Ha Gavin, Freeman Samuel S., Choudhury Atish D., 2017

机译：无细胞DNa的可扩展全外显子组测序显示与转移性肿瘤高度一致
13. Human Cholinesterase Gene Expression in Mammalian Cells: Proposed Nomenclaturefor Human Butyrylcholinesterase Genetic Variants Identified by DNA Sequencing [R] . Lockridge, O., La Du, B. N., Bartels, C. F., 1991

机译：人类胆碱酯酶基因在哺乳动物细胞中的表达：通过DNa测序鉴定的人丁酰胆碱酯酶遗传变异的拟议命名法

Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma

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