End-to-end continuous manufacturing: chemical synthesis, workup and liquid formulation

摘要

Today profitable and competitive methods of manufacturing focus towards end-to-end continuous manufacturing, which is becoming successively a strategic core competence to each manufacturer in the chemical and pharmaceutical industry. Fully integrated continuous upstream and downstream processes combine all the stages of the production process starting from multi-step chemical synthesis down to workup like purification, crystallization, filter and drying, blending and formulation to finally get the finished product. The shift to continuous end-to-end manufacturing faces several challenges which need to be overcome by a tight collaboration and knowledge transfer between several branches and technology suppliers.