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Design and antimicrobial activities of LLLL ‐37 derivatives inhibiting the formation of Streptococcus mutansStreptococcus mutans biofilm

机译：抑制链球菌的形成链球菌的形成的设计和抗微生物活性抑制链球菌的形成

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摘要

Abstract > Dental plaque is closely related to the occurrence of dental caries, of which the main causative bacterium is Streptococcus mutans ( S.?mutans ). In this study, to create potent antibiofilm agents, we chose a human antimicrobial peptide <fc>LL</fc> ‐37 as our starting material and modified it by cutting it shorter and varying its charge and hydrophobicity. The results of anti‐ S.?mutans as well as biofilm inhibitory activity tests indicated that two derivatives, <fc> IG </fc> ‐13‐1 and IG‐13‐2 , were the most potent one toward both planktonic and biofilm S.?mutans cells with the minimal inhibitory concentration of 5.0?μM and minimal biofilm inhibitory concentrations of 5.91?±?0.91?μM and 7.58?±?0.23?μM, respectively. The modes of action study showed that <fc> IG </fc> ‐13‐1 and IG‐13‐2 were functioned by disrupting the bacterial membrane, causing the leakage of inner contents, thereby leading to the death of bacterial cells eventually. In addition, <fc> IG </fc> ‐13‐1 and IG‐13‐2 were able to suppress the expression of proinflammatory cytokine of <fc>TNF</fc> ‐α and reduce the level of nuclear transcription factor‐κB, which indicated the potential anti‐inflammatory activity of these peptides. Conclusively, this study indicated that <fc> IG‐13‐1 and IG‐13‐2 </fc> are potent peptides in both anti‐ S.?mutans and anti‐inflammatory </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>None </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16096/'>《Chemical biology and drug design》</a> <b style="margin: 0 2px;">|</b><span>2019年第6期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Zhao&option=202" target="_blank" rel="nofollow">Chen Zhao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Guang&option=202" target="_blank" rel="nofollow">Yang Guang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Shengsheng&option=202" target="_blank" rel="nofollow">Lu Shengsheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Daiwei&option=202" target="_blank" rel="nofollow">Chen Daiwei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fan Sheng&option=202" target="_blank" rel="nofollow">Fan Sheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Junyang&option=202" target="_blank" rel="nofollow">Xu Junyang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Buling&option=202" target="_blank" rel="nofollow">Wu Buling;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Jian&option=202" target="_blank" rel="nofollow">He Jian;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of StomatologySouthern Medical UniversityGuangzhou China;</p> <p>Group of Peptides and Natural Products ResearchSouthern Medical UniversityGuangzhou China;</p> <p>Group of Peptides and Natural Products ResearchSouthern Medical UniversityGuangzhou China;</p> <p>Group of Peptides and Natural Products ResearchSouthern Medical UniversityGuangzhou China;</p> <p>Group of Peptides and Natural Products ResearchSouthern Medical UniversityGuangzhou China;</p> <p>Department of StomatologySouthern Medical UniversityGuangzhou China;</p> <p>Department of StomatologySouthern Medical UniversityGuangzhou China;</p> <p>Group of Peptides and Natural Products ResearchSouthern Medical UniversityGuangzhou China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6411.html" title="化学药理学">化学药理学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimicrobial peptide&option=203" rel="nofollow">antimicrobial peptide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biofilm inhibitory activity&option=203" rel="nofollow">biofilm inhibitory activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dental plaque&option=203" rel="nofollow">dental plaque;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Streptococcus mutans&option=203" rel="nofollow">Streptococcus mutans;</a> </p> <div class="translation"> 机译：抗微生物肽;生物膜抑制活性;牙菌斑;链球菌变异; </div> </li> <li> <span class="lefttit">入库时间</span> <span>2022-08-20 17:11:57</span> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_international-journal-oral-science_thesis/0201290722929.html">Molecular mechanisms of inhibiting glucosyltransferases for biofilm 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L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lamberts, B. L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pederson, E. D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Pederson, E. D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Simonson, L. G.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Simonson, L. G. </a> <span>1985</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：碱性和酸性合成多肽对口服细菌，变形链球菌和血链球菌对羟基磷灰石粘附的影响</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_international-journal-oral-science_thesis/0201290932514.html">Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qiong Zhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Qiong Zhang</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qizhao Ma&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Qizhao Ma</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Yan Wang</a> <span> <a href="/journal-cn-39271/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 国际口腔科学杂志 </a> </span> <span> . 2021</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_international-journal-oral-science_thesis/0201262696097.html">Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li-na Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Li-na Li</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li-hong Guo&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Li-hong Guo</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Renate Lux&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Renate Lux</a> <span> <a href="/journal-cn-39271/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 国际口腔科学杂志 </a> </span> <span> . 2010</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313359557.html">Molecular Microbial Characterization of Dental Plaque/Biofilm and to detect the Effect of Lactobacillus species on Biofilm Formation of Streptococcus mutans</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ayaz Ahmed&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Ayaz Ahmed</a> <span> . 2012</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130446059075.html">The method for production of egg containing anti-Streptococcus mutans IgY anti-Streptococcus sanguis IgY and anti-Actinomyces israelii IgY individually and egg yolk IgY thereof and ice-cream containing complexing specific IgY for anti-Streptococcus mutans anti-Streptococcus sanguis and anti-Actinomyces israelii</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR20020056612A </span> <span> . 2002-07-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：分别含有抗变形链球菌IgY，抗血链球菌IgY和以色列抗放线菌IgY及其蛋黄IgY的蛋的生产方法和含有抗变链球菌抗链球菌和抗放线菌的复合特异性IgY的冰淇淋以色列 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130406068579.html">COMPOSITION FOR INHIBITING BIOFILM FORMATION BY STREPTOCOCCUS MUTANS COMPRISING RAFFINOSE AS EFFECTIVE COMPONENT</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR20180006800A </span> <span> . 2018-01-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：含有链烷烃作为有效成分的链霉菌突变抑制生物膜形成的组合物 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130412485824.html">Tooth filling materials and dental varnish for inhibiting the formation of a biofilm of <I>Streptococcus mutans </I>and the production thereof</a> <b>[P]</b> . <span> 外国专利： <!-- 美国专利： --> US9320682B2 </span> <span> . 2016-04-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：抑制<I>变形链球菌</ I>生物膜形成及其生产的牙齿填充材料和牙科清漆 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" 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